Deuling dynamo Yu-Gi-Oh and his faithful friends battle their way through crazy games with high stakes and high risks! Tenth-grader Yugi always had his head in some game—until he solved the Millennium Puzzle, an Egyptian artifact containing the spirit of a master gambler from the age of the pharoahs! Possessed by the puzzle, Yugi becomes Yu-Gi-Oh, the King of Games, and challenges evildoers to the Shadow Games…weird games with high stakes and high risks! It’s Yugi and Kaiba vs. the Rare Hunters in a tag team match atop a 13-story skyscraper. But a fate worse than death awaits Yugi when he finds out Mai and Jonouchi have been possessed by Marik! Brainwashed by the evil mastermind, Jonouchi fights to kill his best friend. Will he succeed?
Release on 1988-06-09 | by Joseph Needham,Dieter Kuhn
Author: Joseph Needham,Dieter Kuhn
Pubpsher: Cambridge University Press
This study, the first of two parts, gives a comprehensive account of Chinese textiles and textile technology and deals with the evolution of bast fibre spinning and silk-reeling in the history of China. These operations are the basic techniques in the production of yarn and thread, pre-requisite to weaving, and any study of Chinese textile technology must start with the raw material obtained from fibre plants such as hemp, ramie, jute, cotton, etc, and silk reeled off from cocoons of the domestic silkworm. The time-span covered runs from the neolithic to the nineteenth century. Archaeological and pictoral evidence, the bulk of it hitherto unpublished in the West, is brought together with Chinese textual sources (which are extensively translated and interpreted) to illustrate Chinese achievements in this field. Professor Kuhn's study reveals the way in which Chinese textile-technological inventiveness has influenced textile production in other regions of the world and in medieval Europe. It explains how textile technology reached its high point between the tenth and thirteenth centuries and attempts to indicate the reasons for its subsequent relative decline. The development of the textile industry in Europe was a key factor in the rise of capitalism. In the case of China after Sung times, textile technology and the organisation of textile labour may help indicate why such a development did not take place in China.
Recipes for Economic Development in the Reform Era
Author: Jae Ho Chung
Category: Social Science
This volume, written by contributors from a number of different specialisms, suggests that different combinations of factors have contributed to the relative successes and failures in these cities. Endowment factors, preferential policies, and history have all proved to be important. Most importantly, Cities in Post-Mao China suggests that locally-generated strategies of development are crucial determinants. This ground-breaking volume reveals through close detail and broad coverage how exactly cities have been catalysts for Chinas economic development. It will provide much needed data for those working in the fields of comparative politics, development studies, economic development and Asian studies.
Release on 2012-12-06 | by Yu.A. Kravtsov,Yu.I. Orlov
Author: Yu.A. Kravtsov,Yu.I. Orlov
Pubpsher: Springer Science & Business Media
Caustics, Catastrophes and Wave Fields in a sense continues the treatment of the earlier volume 6 "Geometrical Optics of Inhomogeneous Media" in the present book series, by analysing caustics and their fields on the basis of modern catastrophe theory. This volume covers the key generalisations of geometrical optics related to caustic asymptotic expansions: The Lewis-Kravtsov method of standard functions, Maslov's method of caonical operators, Orlov's method of interference integrals, as well as their modifications for penumbra, space-time, random and other types of caustics. All the methods are amply illustrated by worked problems concerning relevant wave-field applications.
Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the understanding of NK cell biology, these studies are critical for effective translation of NK-based immunotherapy principles into the clinic. In humans, dominant inhibitory signals are transduced by Killer Immunoglobulin Like Receptors (KIR) recognizing cognate HLA class I on target cells. Conversely, KIR recognition of “missing self-HLA” - due to HLA loss or HLA/ KIR mismatch - triggers NK-mediated tumor rejection. Initially observed in murine transplant models, these antitumor effects were later found to have important implications for the clinical outcome of haplotype-mismatched stemcell transplantation. Here, donor NK subsets protect against acute myeloid leukemia (AML) relapse through missing self recognition of donor HLA-C allele groups (C1 or C2) and/or Bw4 epitope. These studies were subsequently extended by trials investigating the antileukemia effects of adoptively transferred haplotype-mismatched NK cells in non-transplant settings. Other mechanisms have been found to induce clinically relevant NK cell alloreactivity in transplantation, e.g., post-reconstitution functional reversal of anergic NK cells. More recently, activating KIR came into the spotlight for their potential ability to directly activate donor NK cells through in vivo recognition of HLA or other ligands. Novel therapeutic monoclonal antibodies (mAb) may optimize NK-mediated effects. Examples include obinutuzumab (GA101), a glyco-engineered anti-CD20 mAb with increased affinity for the FcγRIIIA receptor, enhancing antibody-dependent cellular cytotoxicity; lirilumab (IPH2102), a first-in-class NK-specific checkpoint inhibitor, blocking the interaction between the major KIR and cognate HLA-C antigens; and elotuzumab (HuLuc63), a humanized monoclonal antibody specific for SLAMF7, whose anti-myeloma therapeutic effects are partly due to direct activation of SLAMF7-expressing NK cells. In addition to conventional antibodies, NK cell-targeted bispecific (BiKEs) and trispecific (TriKEs) killer engagers have also been developed. These proteins elicit potent effector functions by binding target ligands (e.g., CD19, CD22, CD30, CD133, HLA class II, EGFR) on one arm and NK receptors on the other. An additional innovative approach to direct NK cell activity is genetic reprogramming with chimeric antigen receptors (CAR). To date, primary NK cells and the NK92 cell line have been engineered with CAR specific for antigens expressed on multiple tumors. Encouraging preclinical results warrant further development of this approach. This Research Topic welcomes contributions addressing mechanisms of NK-mediated activation in response to disease as well as past and contemporary strategies to enhance NK mediated reactivity through control of the interactions between NK receptors and their ligands.
After two volumes mainly introductory, Dr Needham now embarks upon his systematic study of the development of the natural sciences in China. The Sciences of the Earth follow: geography and cartography, geology, seismology and mineralogy. Dr Needham distinguishes parallel traditions of scientific cartography and religious cosmography in East and West, discussing orbocentric wheel-maps, the origins of the rectangular grid system, sailing charts and relief maps, Chinese survey methods, and the impact of Renaissance cartography on the East. Finally-and here Dr Needham's work has no Western predecessors-there are full accounts of the Chinese contribution to geology and mineralogy.
Advances in cancer research over the recent decades have been plentiful and often successful, with 5 year survival rates increasing almost uniformly across the board. The advent of new technologies has presented solutions for yesterday’s barriers to research, allowing us to leap forward in our ability to prevent, diagnose, and treat various cancers. Developments in omics studies has provided new insights into the underlying molecular basis of different cancers and their subtypes, greatly enhancing our understanding of the vast heterogeneity that exists. Progress in our ability to diagnose and detect early-stage cancers has resulted in numerous screening and prevention programs. Novel imaging technologies allow us to study and comprehend cancers with greater clarity than ever before. Although the field, as a whole, has experienced many successes, arduous challenges must be overcome in order to see continued success. The truth of the matter is cancer related deaths continue to rise in number worldwide, especially in lower- and middle-income countries. It is evident that there is still a lot of work to be done. This Frontiers in Oncology Special Issue marks the 1st edition of a collection of selected articles published in the journal over the course of the previous calendar year, highlighting ongoing research and advances being carried out in the different disciplines of cancer research.